Best 5 Phentermine Over-The-Counter Brands To Lose Weight In 2023, Top Natural Phentermine Alternative OTC

As of the start of 2023 the most frequently prescribed diet pill in the United States is Phentermine, an FDA approved appetite suppressant. Phentermine 37.5 mg  is not available or suitable for everyone, it can only be obtained by prescription, it can also cause several side effects. For these reasons a thriving market has evolved for over the counter Phentermine alternatives. This article is a comprehensive guide and compares, reviews and rates the best phentermine over the counter brands for 2023.

5 Best OTC Phentermine Alternatives 2023

Here are the 5 best OTC Phentermine alternatives available to buy this year.

1.    PhenQ: Best Phentermine alternative overall

2.    Phen24 : Best Phentermine-over-the-counter controlling hunger at night

3.    PhenGold : Best OTC Phentermine for fighting fatigue

4.    Leanbean : Top Phentermine alternatives for menopausal women

5.    Prime Shred : Best Phentermine substitute for bodybuilding and sports

Although the first three diet pills were developed especially for people seeking safe OTC alternatives to Phentermine, Leanbean and Prime Shred were not.

However, both natural dietary supplements work well for weight loss and regularly appear on “best diet pills” lists published on credible sites. We have included them here based on their abilities and reputations for delivering excellent results. 

The term ‘phentermine over the counter’ (also known as OTC) refers to a weight loss pill or appetite suppressant supplement that helps you lose weight without the need for a prescription from a doctor.

#1. PhenQ: Best Phentermine-Over-the-Counter Overall


CLICK to view PHENQ price – availability and latest offers 

PhenQ is critically acclaimed and arguably the most effective Phentermine-over-the-counter brand. As of 2023 it has already helped more than 320,000 men and women to lose weight and has no known side effects.

PhenQ is suitable for most people who need a strong weight loss pill to help them to lose weight quickly and safely. That includes vegans and vegetarians.

Losing weight with PhenQ is a multi faceted weight loss process – it can burn body fat, suppress appetite and control food cravings and also stop new fat cells from forming. 

It is also the OTC diet pill that offers people the greatest level of support. Its unique five-pronged approach to weight loss is one of the main reasons over 300,000 people report such sterling results. PhenQ is the best over-the-counter diet pill for 2023 according to industry critics.

When you choose PhenQ as a Phentermine-over-the-counter, these are the benefits you can expect:

●    Controlled hunger and sugar cravings

●    Faster fat burning

●    Protection from body fat storage

●    Extra energy/protection from diet-related fatigue

●    Improvements in mood and mental clarity

There’s one other important benefit you get when you choose PhenQ, a 60-day money-back guarantee.

When PhenQ was launched, most non-prescription weight loss pills did not have money-back guarantees and, with the few that did, 30 days was as good as it got.

PhenQ’s 60-day guarantee was present right from the start. It broke new ground and forced many other diet-pill manufacturers to change their ways. That’s a pretty nice claim to fame.

CLICK to view PhenQ Phentermine OTC price and offers

How PhenQ Works (Key Weight Loss Ingredients)

PhenQ provides seven natural ingredients that have science-backed weight loss enhancing capabilities. We already mentioned one of them, caffeine, and it’s more useful than you think.

In addition to being one of the best natural ingredients for boosting energy and concentration, caffeine is also a proven fat burner.

Although some research suggests caffeine’s ability to influence weight loss is modest, it’s mainly included in PhenQ as an energy booster. However, its ability to support fat loss is a useful bonus. [1, 2]

Much of the formulation’s ability to control hunger is due to nopal (Caralluma fimbriata). Research proves the value of using extracts from this species of cactus for suppressing appetite and reducing waist circumference. [3, 4]

PhenQ also contains α-LACYS RESET. It’s the only supplement that provides it.

α-LACYS RESET is a patented combination of alpha-lipoic acid (ALA) and cysteine. Clinical evidence shows that even acting on its own, ALA can deliver modest improvements in weight loss. [5]

Combining ALA with cysteine appears to enhance its fat-burning potential. However, although many people believe α-LACYS RESET is the most crucial PhenQ ingredient, we disagree. Exciting as its abilities are, α-LACYS RESET is but one part of a truly excellent formulation.

Capsimax is another notable inclusion. It’s a patented version of cayenne that uses a special delivery technology that helps the key compound in capsicum (capsaicin) attain maximum absorption in the gut.

Most of the Phentermine-over-the-counter dietary supplements have cayenne in them, but Capsimax is widely acknowledged to be a superior option.

Research shows the capsaicin that’s naturally present in capsicum peppers supports weight loss in several ways including reducing hunger and accelerating fat burning. [6]

PhenQ Pros:

●    Effective weight loss pill for men and women

●    Most popular phentermine over-the-counter

●    Provides powerful science-backed ingredients

●    Supports weight loss in multiple ways

●    Vegan-friendly and gluten-free

●    Special deals, such as 3 bottles for the price of 2

●    60-day money-back guarantee

PhenQ Cons:

●    Not suitable for people who wish/need to avoid caffeine

●    You can only buy it from the official website

●    It’s such a popular product it often sells out

#2. Phen24: Best OTC Diet pills for Controlling Hunger at Night


CLICK to view PHEN24 price and availability in your country 

Phen24 stands apart from all the other Phentermine-over-the-counter brands because you get two bottles of pills instead of one. More than a supplement, Phen24 is a complete weight management system that’s designed to help you to burn extra fat night and day.

Phen24 Day provides ingredients that help you to lose weight and boost your energy levels as well. Phen24 Night also encourages fat loss but instead of providing energy boosters, it provides an ingredient that helps you to sleep.

A diet pill that helps you to sleep? Seems a little strange doesn’t it? However, a growing body of evidence suggests there is a link between sleep deprivation and obesity. [7]

One of the best things about this Phentermine-over-the-counter alternative is the pill you take at night is heavily geared toward appetite suppression. Because of this, we consider Phen24 the top alternative to Phentermine for anyone who is often tempted to eat before bed or wakes up during the early hours and goes in search of a midnight snack.

Here is a list of the benefits you can expect if you choose to lose weight with Phen24:

●    24-hour increases in metabolism and fat burning

●    Hunger suppression (especially at night)

●    More energy during the day

●    Burns stored fat

●    Improvements in sleep quality

Phen24 is another top-ranking OTC diet pill that has a 60-day money-back guarantee. So, if you decide to use it instead of Phentermine, you can rest easy about your investment. If you don’t get the results you seek, you can ask for your money back.

How Phen24 Works (The Key Ingredients)


When you use these diet pills as an alternative to Phentermine-over-the-counter, you take the daytime pill each morning and two of the nighttime pills before eating your evening meal.

It’s important to take the nightly dose with two glasses of water, not one. Adequate water is necessary to activate the key appetite-suppressing ingredient.

Phen24 Day contains cayenne. When you take it in the morning, it revs up your metabolism to help you to burn more calories and fat during the day. It also suppresses hunger so that you are not tempted to snack during the day or overeat at lunchtime. [6]

Much of the energy boost the daytime supplement provides is due to caffeine. However, although the overall caffeine content is higher than that of PhenQ, a lot of it comes from guarana berry extract.

Guarana dribbles caffeine into your body slowly instead of hitting you with it all at once. This reduces the risk of side effects. It also helps you to retain caffeine’s benefits further into the day.

Each dose of Phen24 provides a full gram of glucomannan fiber. That’s why you need to take two pills instead of one.

Glucomannan is one of the best natural hunger suppressants on the market. It comes from the roots of the Asian konjac plant and is astonishingly absorbent. it can easily soak up 50 times its weight in water.

As it hydrates, the fiber swells inside the stomach, causing it to feel full. An EFSA evaluation of relevant studies shows glucomannan works for weight loss. It also shows 1 gram is the ideal dose. [8]

In addition to reducing nighttime hunger, Phen24 Night also accelerates fat burning. It does this by providing green tea extract. 

Research shows the antioxidants in green tea extract boost metabolism, helping you to burn extra fat. [9]

Hops extract is another important Phen24 ingredient that’s worthy of mention. It has a research-backed ability to aid restful sleep. The benefits don’t end there.

Hops also appear to enhance the body’s ability to burn visceral fat (belly fat). [10, 11]

Phen24 Pros:

●    Provides powerful science-backed ingredients

●    Supports weight loss in several ways

●    Boosts daytime energy levels

●    Aids restful sleep

●    Provides maximum nighttime hunger suppression

●    Vegan-friendly and gluten-free

●    Special deals, such as 3 packs for the price of 2

●    60-day money-back guarantee

Phen24 Cons:

●    The daytime pill has caffeine in it

●    You can only buy it from the official website

#3. PhenGold: Best OTC Phentermine Diet Pill for Fatigue


CLICK to view PHENGOLD price and availability for 2023

PhenGold is another good over the counter alternative to Phentermine. However, although it suppresses appetite the formulation places greater emphasis on boosting energy levels and enhancing the body’s ability to burn fat.

Nevertheless, PhenGold is a safe and effective weight loss aid that works well for 98% of people. That’s very good and there is no need to worry about losing any money if you are one of the unlucky 2% because the manufacturer provides a 100-day money-back guarantee.

If you choose this Phentermine-over-the-counter substitute, you will only need to take one dose per day. If you have a hectic life and normally have to keep a tight schedule, a one-pill-per-day option like this may be very appealing.

Here are the benefits you can expect if you choose to increase your fat loss with PhenGold:

●    Reductions in hunger and food cravings

●    Less fatigue

●    Faster metabolism and weight loss

●    Quickly burn calories

●    Improvements in mood

●    Sharper mental focus

●    Provides and energy boost

Each dose of PhenGold provides 225 mg of caffeine. That’s the caffeine equivalent of three shots of espresso. Although most people should be okay with that, if you choose to use this diet pill instead of Phentermine, it may be best to forget about having a morning cup of coffee.

How PhenGold Works (The Key Ingredients)

As with all the best natural Phentermine alternatives, PhenGold diet pills support fat loss in multiple ways.

The two key fat burners in the formulation are cayenne and green tea. As we explained earlier, cayenne is a versatile ingredient that supports weight loss in other ways as well, including controlling hunger. [6]

Most of PhenGold’s energy-boosting ability is due to caffeine. However, the formulation also contains several B vitamins.

You may have noticed B vitamins are often included in energy drinks. They are not there without good reason. B vitamins enhance the body’s ability to absorb energy from food.

PhenGold provides L-theanine as well. It’s an amino acid that’s often refined from green tea.

Research shows combinations of L-theanine and caffeine can be particularly good for enhancing cognitive function. [12]

PhenGold Pros:

●    Contains ingredients that are scientifically proven to support weight loss

●    Provides multiple benefits

●    Vegan-friendly and gluten-free

●    Special deals, such as 3 packs for the price of 2

●    100-day money-back guarantee

PhenGold Cons:

●    Higher caffeine content than most similar products

●    You can only buy it from the official website

#4. Leanbean: Best Natural Phentermine Alternative for Menopausal Women


CLICK to view LEANBEAN price and availability for 2023 Leanbean was not designed to replace Phentermine but it was created especially for women. Because of this, it contains ingredients that regulate estrogen, helping to prevent menopausal weight gain.

Leabean is also the only natural Phentermine alternative supplement on this list that does not contain any caffeine. If you are looking for a stimulant-free fat burner made for women, this is the best weight loss supplement to choose. 

The main Leanbean weight loss benefits are:

●    Control of your hunger and food cravings

●    Contains natural appetite suppressants

●    Accelerated fat loss

●    Maintain body weight

●    All natural ingredients

●    Energy boost

●    Protection from hormonal issues such as menopausal weight gain

When you choose Leanbean as an OTC alternative to Phentermine, you need to take three doses per day—one before each of your main meals. 

Some women may not relish the thought of having to remember to take so many pills but customer reviews show the benefits Leanbean provides more than justify any minor inconvenience.

How Leanbean Works (The Key Ingredients)

It’s hard for many women to maintain their ideal weights because their hormones often work against them. This is an issue men do not have to contend with.

Women are also more susceptible to hunger than men are. Research suggests this may also be due to hormonal issues. [13]

Regardless of the cause, by providing a hefty dose of glucomannan, three times each day, Leanbean will help women to keep their unruly appetites under control. [8]

Leanbean weight loss supplement contains green coffee bean extract to burn fat and increase energy levels.

The Leanbean diet pill formulation also provides turmeric. Although it has been shown to support increases in fat loss, it’s included in Leanbean, first and foremost, to regulate estrogen, which functions both as a hormone and as a neurotransmitter. [14]

Turmeric provides curcumin. It’s a versatile compound that does many good things in the body, including reducing inflammation. Research involving women experiencing premenstrual syndrome (PMS) shows it can be very effective at reducing the symptoms. [15]

Menopausal weight gain is caused by the same estrogen issues that are so good for triggering PMS but “the change” makes things much worse. Fortunately, by providing curcumin, turmeric can make things a lot better.

Although Leanbean is free from stimulants, the omission does not prevent the formulation from boosting energy. It uses non-stimulant options, such as B vitamins, instead.

This Phentermine alternative’s fat-burning capability is mainly due to choline. Research shows supplementing with this essential nutrient can be very effective for women. In one study, female athletes who received choline supplements experienced rapid weight loss without sacrificing any of their physical strength. [16]

Leanbean Pros:

●    Formulated especially for women

●    Provides multiple weight loss benefits

●    Regulates hormones

●    Stimulant-free fat burner for women

●    Vegan-friendly and gluten-free

●    When you order three bottles you get a fourth one for free (The Complete Bundle)

●    Offer of a 90-day money-back guarantee

Leanbean Cons:

●    Only available via the manufacturer’s website

●    You need to order The Complete Bundle to get the money-back guarantee

#5. Prime Shred: Best OTC Phentermine Alternative for Bodybuilding and Sports

 Prime Shred
Prime Shred

CLICK to view PRIME SHRED price and availability

Prime Shred is another natural weight loss supplement that you can use instead of Phentermine even though it’s not really intended for that role.

Generally more popular with men than it is with women, Prime Shred is a powerful fat burner designed for bodybuilders and other athletic individuals who spend a lot of time training in the gym or hitting the track.

Although Prime Shred is much safer than Phentermine, it’s another diet pill that provides 225 mg of caffeine in a single dose.

That may be a little too much for a minority of people but it’s a splash in the ocean compared to the amount of caffeine many alternative sports supplements provide.

If you decide to use Prime Shred as a Phentermine-over-the-counter weight loss supplement, it will help you to do the following:

●    Lose pure fat

●    Break through plateaus

●    Target fat in stubborn areas

●    Improve your physique

●    Preserves lean muscle mass

●    Get your body leaner and more ripped than ever before

●    Safer than prescription medication

As with all the other supplements we recommend as alternatives to Phentermine, Prime Shred is vegan-friendly and has a money-back guarantee. 

How Prime Shred Works (The Key Weight Loss Ingredients)

In common with all the Phentermine over-the-counter alternatives, Prime Shred is a 100% natural product that harnesses the weight loss boosting abilities of amino acids, nutrients, and plant extracts.

You probably won’t be surprised to learn, green tea and cayenne are included in the line-up. Most of the best diet pills provide one of them or both. Diet pill manufacturers favor them because there is so much proof that these two ingredients work. [6, 9]

The weight loss supplement formulation also contains B vitamins to work alongside caffeine and help people put extra effort into their training or chosen sport(s).

In addition to helping you to train harder, Prime Shred also reduces the risk of burnout if you take things too far. It does this by providing Rhodiola rosea.

It is recommended to use Prime Shred in conjunction with a healthy diet.

Rhodiola rosea is an adaptogen herb. Like all herbs that belong to this category, it provides numerous benefits and is often used as a natural remedy for anxiety and stress.

The results of a clinical trial involving burnout patients are highly supportive of using Rhodiola rosea to reduce or prevent burnout syndrome. [17] 

Prime Shred Pros:

●    Provides proven ingredients to help people lose weight quickly

●    Supports fat loss in several ways

●    Protects against burnout

●    Helps you to attain a shredded physique

●    Special deals available, such as buy 2 bottles, get 1 bottle free

●    100-day money-back guarantee

Prime Shred Cons:

●    Quite high caffeine content

●    Only available from the manufacturer’s website

How We Ranked the Top Phentermine OTC Brands

This is the criteria for ranking the top natural phentermine alternatives.


This is the most important – does it work? Do the ingredients have clinical proof or research backing up the manufacturers claims?


How is the brand viewed by past customers? Are there any bad reviews? Are a majority of the impartial customer reviews overwhelmingly positive.

Customer Service

What is customer service like? If you have a problem with delivery or a purchase can you contact the customer service department easily.


Are the weight loss supplements safe, will they cause side effects? Are there any people that cannot use it?


How much do over the counter Phentermine brands cost? How do they compare to other natural Phentermine substitutes?

What Is Phentermine?

●    Molar mass: 149.233 g/mol

●    Boiling point: 402.8°F (206°C)

●    CAS ID: 122-09-8

●    ChEMBL Id: 1574

●    ChemSpider ID: 4607

●    IUPHAR ID: 7269

●    Metabolism: Liver

Phentermine Hydrochloride is a prescription drug that suppresses appetite. It’s only available to people who have a prescription. It is FDA (Federal Drugs Administration) approved for weight loss for adults.

A popular pharmaceutical weight loss pill, Phentermine HCL was first introduced in 1959. However, although it continues to be available via prescription in the USA, Canada, and Australia, It’s not possible to obtain Phentermine legally in Europe or many other parts of the world.

Prescription Phentermine pills are an amphetamine (speed) derivative. It can be addictive and also presents many side effects. Because of this, the regulatory bodies in many countries state the benefits the drug provides are not great enough to compensate for its risks.

Phentermine 37.5 Dosage

The usual dosage is 37.5 mg and sold under the following brand names.

●    Adipex (USA)

●    Adipex-P (USA, Canada and UK)

●    Atti-Plex P

●    Fastin

●    Ionamin

●    Duromine (Australia)

What Do Phentermine Pills Look Like

Phentermine pills are very distinctive – they are small white oval shaped tablets with blue flecks. They also may be marked as 37.5 or 375 HCL.

Unlike the natural diet pills, many people buy in store or online without prescription and use instead, Phentermine diet pills are only intended for short-term use. It’s available via prescription for up to 12 weeks and many people do not receive it for that long.

After the drug is absorbed into the blood, it stimulates neurotransmitters in the brain, causing a condition known as fight or flight. It’s a survival mechanism that’s been with our species since primitive times.

Fight or flight tweaks the body in numerous ways that help ensure survival. One of the things it does is increase adrenaline. It also makes the eyes and ears more sensitive and boosts mental alertness. 

These and many other changes enhance reflex action and increase stamina and strength, making it easier to run away (flight), or fight for your life.

In a life or death situation, hunger could be a potentially lethal distraction so fight or flight cuts the sensation off at the source. This is the part of the fight or flight response Phentermine aims to abuse.

We use the term “abuse” because the drug forces the body to maintain the condition for several hours. This places the body under tremendous strain.

Phentermine-Over-the-Counter – What Does it Actually Mean

The term ‘phentermine over the counter’ (also known as OTC) is a weight loss pill or appetite suppressant supplement that helps you lose weight without the need for a prescription from a doctor.

Can I Buy Phentermine Over the Counter

If you are hoping to buy real Phentermine diet pills over the counter (OTC) in 2023, you are out of luck. Often sold under the Adipex brand name, Phentermine is only available to people who arrive at pharmacies armed with a doctor’s prescription.

If learning of the distribution restrictions has blown a hole in your day, don’t let it. The truth is, Phentermine’s ability to support weight loss is overrated. Although it works well for most people, there are also plenty of Phentermine users who do not lose any weight at all.  

Phentermine is not the weight loss magic pill many people think it is. It only controls hunger. Many of the OTC diet pills people use instead of Phentermine can do this too.

However, all the best options provide help in other ways as well, such as increasing metabolism. By doing this alone, the best OTC alternatives to Phentermine help you to burn more calories per day.

Appetite suppressants only make weight loss easier by helping you to stick to your diet. They are useful but are not geared toward shifting anyone’s fat-burning capabilities into overdrive.

Although people often hear tales about people losing weight with Phentermine, the drug’s ability to cause severe—even life-threatening—side effects is often ignored. Many potential Phentermine users also have no idea the drug the pill provides can be addictive.

Phentermine side effects can be so unpleasant that many people who get it via prescription cease the treatment and use safer OTC diet pills instead. Other potential users refuse the offer of a prescription because they don’t like the possibility of addiction.

Fortunately, there are several OTC diet pills that offer results that are similar to or better than Phentermine. The best of them have no known side effects and money-back guarantees.

Phentermine Side Effects

If you are thinking of using legit Phentermine as a weight management drug, you need to be aware that experts at Harvard state chronic activation of flight impairs health. [18]

One of the things fight of flight does is elevate blood pressure. Once you know that, it should not surprise you to learn that authentic Phentermine weight loss pills’ side effects include headaches, nose bleeds, heart attacks, and strokes.

Although some of the side effects this weight loss drug can cause are alarming and have the potential to end life, you need to remember people who are using Phentermine legally are doing so under their doctor’s supervision.

However, due to the level of risk involved, it’s highly unlikely any doctor would prescribe this drug to people who already have heart disease or high blood pressure. Nor are they likely to prescribe it to women who are pregnant or breastfeeding a child.

In addition to being a survival mechanism, fight or flight is also a stress response. Because of this, anxiety and stress are two more possible side effects.

Some people that are on Phentermine prescription medication find the drug causes depression too. Other potential side effects include mood swings, low libido.

Little wonder so many people decide against using prescription Phentermine and seek out safer OTC Phentermine alternatives instead.

Prescription Weight Loss Medication Cautions

Prescription medications such as Phen are not suitable for pregnant or nursing women or anybody currently on other medication.

Benefits of Choosing a Natural Alternative to Phentermine Diet Pills

Most of the top OTC Phentermine alternatives can suppress appetite to a level that’s comparable to Phentermine. However, even options such as PhenGold, which offers a lesser level of appetite support, can still outperform the drug at the scales.

By increasing metabolism and providing support in additional areas, these premium natural weight loss supplements can significantly enhance the body’s ability to burn fat.

One of the best things about the top OTC alternatives is they do not place the body into fight or flight. Even options that are higher in caffeine, such as Prime Shred, are infinitely safer than Phentermine and pose zero threat of addiction.

The other good thing about OTC natural supplements is, unlike prescription Phentermine, you can use them long-term. When people have a lot of weight to lose, it’s generally going to take them longer than 12 weeks to do it.

These safer, natural alternatives are also easier to obtain and, as we have already pointed out, all the best options come from manufacturers who are willing to guarantee their supplements’ ability to work.

Phentermine-Over-the-Counter Summary and Conclusions

Are you considering using a potent appetite suppressant to help you reach your weight loss goals for 2023? If so, natural otc Phentermine alternatives should be high on your list. 

Some of the best phentermine alternative supplements can not only suppress appetite but ignite your fat burning hormones. 

PhenQ is regarded to be among the best phentermine alternatives, if not the best. PhenQ can burn excess body fat, reduce hunger and stop the formation of new fat cells. If that is not enough this phentermine-over-the counter alternative can also reduce diet related tiredness and improve your mood.

Disclaimer: The above is a sponsored post, the views expressed are those of the sponsor/author and do not represent the stand and views of Outlook Editorial.




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